A Dent in The Denture Business: Regrowing Teeth
It’s not here yet, but in the future, the technology may exist to
allow dental patients to actually regrow teeth by planting
“seeds” in their jaws for new teeth.
Sound farfetched?
Well, don’t look now, but it has already been done in mice. This has
successfully been done by some sicentists, and they say it may be
possible to develop the process to work in humans.
It would actually be a cheaper and more accessible alternative to
the current solution of tooth implants. At present time, titanium
tooth implants are believed to be best, but this upcoming science of
regrowing teeth appears promising.
A University of Tokyo research team lead by Professor Takashi Tsuji
have been able to grow a tooth “seed” in a lab, transplant it into
a rodent’s jaw, and observe it mature into a tooth of standard
appearance with all the normal structures. Enamel and blood vessels
were present, in evidently standard form.
The team was able to observe the process at a finer level too, in
attempts to verify that the new teeth are bona fide teeth. They
used a fluorescent protein to track genes in the transplanted
tooth “bud”. The researchers discovered that the genes that are
normally active while a tooth develops were also functioning during
the transplanted bud’s growth.
In addition, the new tooth had similar hardness to ordinary teeth.
Pain stimulation responses showed that nerve fibres were able to grow
throughout the bioengineered tooth.
Some readers may be aware that existing technology allows organ tissue
to be grown in a laboratory, which can tehn be transplanted into
animals. Howvever, the growing of new teeth is the first instance of
a living animal having a three-dimensional organ grown inside it,
starting with only a few cells.
Furthermore, the team’s leader, Professor Tsuji, has stated that the
technique may be adatable to allowing the regrowth of damaged organs
within patients.
“This study demonstrates a technique that could lead to
the development of bioengineered organ replacements, potentially
providing a prelude to the ability to grow new, fully functional
organs inside the body from stem cells or other germ cells.”
The study has been published in the proceedings of the National
Academy of Sciences . It emphasizes that the teeth were “fully
functioning”, had the correct structure, strength of mineralised
tissues for chewing, and pain response.
Professor Tuji elaborated:
“We propose this technology as
a model for future organ-replacement therapies. This study represents
a substantial advance and emphasises the potential for bioengineered
organ replacement in future regenerative therapies.”
The president of the British Dental Association, and senior
lecturer in restorative dentistry from the University of Dundee,
John Drummond, remarked that the successful implantation of a
tooth bud may herald a new era in dentistry.
“This sort of development is probably the future,” he said.
“Something like this has a huge potential to replace teeth that have been
lost.”
“I would guess we are at least a decade away from this
being available to patients because so many clinical trials and tests
have to be carried out. But it has the potential to be a lot less
expensive than something that involves a titanium implant into the
jaw.Potentially, the surgery involved in something like this could be a
lot more straightforward. It could very well be something every
dentist would be able to do.”
